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Managing Misfolded Proteins to Prevent Parkinson's Disease

The protein alpha-synuclein is abundant in healthy brains and plays an important role in enabling communication between nerve cells. However, under certain conditions, misfolded alpha-synuclein proteins can accumulate into toxic clumps inside neurons. Known as Lewy bodies, these clusters of proteins are a hallmark of Parkinson's disease and some forms of dementia.

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