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Bugs as Drugs: Engineered Gut Bacteria Show Promise Against Pancreatic Cancer

Cancer immunotherapies have transformed treatment for many cancers, but pancreatic cancer remains especially difficult to treat. One major reason is that pancreatic tumors often create a "cold" tumor microenvironment, where the tumor prevents immune cells from mounting a strong attack.In a new study published in Science Advances, researchers at the University of Chicago report a promising new strategy to overcome this barrier using BifidoSumIL-2, an engineered bacterial strain of Bifidobacterium longum, a probiotic bacterium naturally found in the gut, to deliver an immune-stimulating therapy directly inside tumors.

July 24, 2026


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