News for Healthier Living
Saffron Compound Shows Promise Against Fatty Liver Disease
 A research team has identified Crocin II, a natural compound derived from saffron, as a promising therapeutic candidate for metabolic dysfunction-associated steatotic liver disease (MASLD). The study shows that Crocin II directly targets angiopoietin-like protein 8 (ANGPTL8), a liver-derived regulator of lipid metabolism and inflammation, and promotes its degradation through the autophagosome-lysosome pathway. By reducing ANGPTL8 protein levels, Crocin II alleviated liver fat accumulation, improved lipid profiles, reduced inflammatory changes, and enhanced glucose and insulin responses in experimental models.
July 16, 2026
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