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Wistar Institute and Temple Scientists Identify Metabolic Target to Overcome Chemotherapy Resistance in Ovarian Cancer

Many cancers can be treated by administering DNA-damaging agents, such as platinum-based chemotherapy, because the resulting DNA damage causes the cancer cells to die. A subset of cancers, however, including ovarian cancers, can repair their own DNA. Because such cancers survive despite chemotherapy, ovarian cancer patients whose tumors are DNA repair proficient have historically faced a poor prognosis and commonly recur within six months.

May 27, 2026


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