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Genes Tied to Impulse Control Play a Major Role in Addiction Risk

Most of the genetic risk for developing a substance use disorder comes from genes that broadly affect how our brains process rewards, regulate impulses and weigh consequences - not from genes that specifically influence substance use disorder or any single drug. Researchers of a Rutgers Health-led study headed by Holly Poore, a faculty instructor of psychiatry at Rutgers Robert Wood Johnson Medical School, analyzed genetic data from previously published genome-wide association studies totaling more than 2.2 million individuals to understand how genes shape vulnerability to alcohol, tobacco, cannabis and opioid use disorders.

March 20, 2026


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