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BGB-A445, a novel non-ligand-blocking agonistic anti-OX40 antibody, exhibits superior immune activation and antitumor effects in preclinical models

This study finds BGB-A445, a non-ligand-competitive anti-OX40 antibody under clinical investigation, induces T cell activation, depletes regulatory T cells, shows robust antitumor efficacy in a mouse model, synergizes with anti-PD-1, and is superior to ligand-competitive ones, warranting further clinical study.

September 24, 2025


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