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Tumor Allies or Foes? Unraveling Neutrophil Roles in Cancer

Neutrophils, once considered simple foot soldiers of innate immunity, are now recognized as complex players in cancer. This review highlights how these cells, which typically defend the body from infection, can paradoxically support tumor progression through promoting angiogenesis, immune suppression, and metastasis. Yet, they also possess tumor-fighting capabilities under certain conditions. The dual nature of tumor-associated neutrophils (TANs)--either aiding or attacking cancer--depends on various signals within the tumor microenvironment. Understanding this plasticity opens doors to novel therapeutic strategies that can suppress their tumor-promoting roles while enhancing their anti-tumor potential.

July 28, 2025


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