News for Healthier Living
Blocking a Little-Known Protein May Offer New Hope for Devastating Lung Disease
 Researchers at the Icahn School of Medicine at Mount Sinai and collaborators have identified a previously overlooked protein, Epac1, as a key driver of idiopathic pulmonary fibrosis (IPF), a chronic and progressive lung-scarring disease. Their findings, demonstrated across cell cultures, preclinical models, and samples of human lung tissue, show that blocking Epac1 can slow the progression of the disease. Published in the July 7 online issue of European Respiratory Journal [https://doi.org/10.1183/13993003.02250-2024], the work could pave the way for a new class of treatments to help patients with this currently incurable condition.
July 15, 2025
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